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Home - Products - Cell Cycle/DNA Damage - Potassium Channel - Mitiglinide calcium

Mitiglinide calcium

CAS No. 145525-41-3

Mitiglinide calcium( KAD-1229 | S-21403 )

Catalog No. M11966 CAS No. 145525-41-3

An insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Mitiglinide calcium
  • Note
    Research use only, not for human use.
  • Brief Description
    An insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells.
  • Description
    An insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells; has potent hypoglycemic effects.Diabetes Approved.
  • In Vitro
    Mitiglinide Calcium inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 value, 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells.
  • In Vivo
    Mitiglinide Calcium (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load. Animal Model:Pregnant Wistar rats (12 weeks) Dosage:0.3 mg/kg, 1 mg/kg, 3 mg/kg Administration:Oral administration Result:Dose-dependently suppressed AUC glucose levels.
  • Synonyms
    KAD-1229 | S-21403
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    ATP-sensitiveK+channels
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    145525-41-3
  • Formula Weight
    334.44
  • Molecular Formula
    C19H24NO3Ca0.5
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1CCC2CN(CC2C1)C(=O)CC(CC3=CC=CC=C3)C(=O)[O-].C1CCC2CN(CC2C1)C(=O)CC(CC3=CC=CC=C3)C(=O)[O-].[Ca+2]
  • Chemical Name
    2H-Isoindole-2-butanoic acid, octahydro-γ-oxo-α-(phenylmethyl)-, calcium salt (2:1), (αS,3aR,7aS)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ohnota H, et al. J Pharmacol Exp Ther. 1994 May;269(2):489-95. 2. Ohnota H, et al. Biochem Pharmacol. 1995 Jan 18;49(2):165-71. 3. Kinukawa M, et al. Br J Pharmacol. 1996 Apr;117(8):1702-6.
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